ATTO Products

Easy-to-Handle

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Polyacrylamide gel is a polymer in which acrylamide and N, N’-Methylenebisacrylamide (Bis), a crosslinking agent, are bonded by radical polymerization. Acrylamide forms a linear structure and the crosslinking agent acts as a bridge to form a polymer (gel) with a net structure. The lower the gel concentration, the larger the pore size, so high molecular protein separation is possible. However, Bis has low solubility, so it becomes a non-uniform gel due to clumps. Non-uniform gels fall in strength and tear easily. Therefore, the problem was that it was difficult to handle.
This time, ATTO succeeded in developing a uniform gel at low concentrations using a new crosslinking agent with higher solubility and longer bonding arms than Bis. It has excellent strength with tensile fracture stress about 1.7 times higher than Bis. In addition, with large pore size, the sample smoothly enters the gel’s net structure without clogging, showing higher separability.